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Nature Serves Our Health. 24hr Supplement Makes It Better

We are scientists and doctors who develop innovative and formulate effective daily supplements for optimal health using natural ingredients supported by scientific evidence. Our common goal is to investigate answers to the body’s primary nemesis: Oxidative Stress, which leads to a wide range of illness and disease. That’s why every 24hr Supplement contains a core ingredient, TurmiZn-OS™. Derived from the wonder spice Turmeric, TurmiZn-OS™ delivers an anti-oxidant, anti-inflammatory and anti-bacterial triple-combo complex of Curcumin, Zinc and Tetrahydrocurcumin. Bonded together, these ingredients harness the power to support the immune system, disrupt premature aging, and promote healing from other conditions impacting joint, cardiovascular, brain health and much more. 

Scientific evidence and clinical research guides our decisions on which ingredients go into our products. In our Immunity product alone, thousands of studies show the 10 ingredients that make up the supplement benefit human health. As we like to say, “The Proof Is In The Science.” 

Below are a sampling of studies that support our work which supports the health of virtually every organ in the body: 

Our Innovation: TurmiZn-OS™ 

  • Tran Quang Hieu, Doan Thi Thanh Thao, Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities, Journal of Chemistry, vol. 2019, Article ID 8082195, 8 pages, 2019. https://doi.org/10.1155/2019/8082195 
  • Sareen R, Jain N, Dhar KL. Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects. Pharm Dev Technol. 2016 Aug;21(5):630-5. doi: 10.3109/10837450.2015.1041042. Epub 2015 Apr 29. PMID: 25923136. 
  • Ji HF, Shen L. Can improving bioavailability improve the bioactivity of curcumin? Trends Pharmacol Sci. 2014;35(6):265‐266. 
  • Wanninger S.,  Lorenz V.,  Subhan A. and  Edelmann F.T.  Metal complexes of curcumin – synthetic strategies, structures and medicinal applications. Soc. Rev., 2015, 44, 4986. 
  • DuBourdieu, D. The Immunity Enemy, Blog, published June 4, 2021. 

 

Turmeric: Curcumin, Tetrahydrocurcumin 

  • Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Molecular Nutrition & Food Research. 2013;57(9):1510‐1528. 
  • Prasad S, Aggarwal BB. Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In : Benzie IFF, Wachtel‐Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. Boca Raton(FL)2011. 
  • Siviero A, Gallo E, Maggini V, et al. Curcumin, a golden spice with a low bioavailability. Journal of Herbal Medicine. 2015;5(2):57‐70. 
  • Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 2014;20(1):185-205. 
  • Xi J, Luo X, Wang Y, Li J, Guo L, Wu G, Li Q. Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp Ther Med. 2019 Nov;18(5):3681-3687. doi: 10.3892/etm.2019.7974. Epub 2019 Sep 5. PMID: 31602247; PMCID: PMC6777287. 
  • Chen BL, Chen YQ, Ma BH, Yu SF, Li LY, Zeng QX, Zhou YT, Wu YF, Liu WL, Wan JB, Yang Y, Li CW. Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. Clin Exp Allergy. 2018 Nov;48(11):1494-1508. doi: 10.1111/cea.13258. Epub 2018 Sep 12. PMID: 30137697. 

Vitamins C, D, Zinc 

  • Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune SystemWorking in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12(1):236. Published 2020 Jan 16. doi:10.3390/nu12010236 
  • Paola Bonaventura, Giulia Benedetti, Francis Albarède, Pierre Miossec, Zinc and its role in immunity and inflammation, Autoimmunity Reviews, Volume 14, Issue 4, 2015, Pages 277-285, ISSN 1568-9972. 

Disease 

  • Al-Ali K, Abdel Fatah HS, El-Badry YA. Dual Effect of Curcumin-Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats. Biol Pharm Bull. 2016;39(11):1774-1780. doi: 10.1248/bpb.b16-00137. PMID: 27803448. 
  • Marton LT, Pescinini-E-Salzedas LM, Camargo MEC, Barbalho SM, Haber JFDS, Sinatora RV, Detregiachi CRP, Girio RJS, Buchaim DV, Cincotto Dos Santos Bueno P. The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Front Endocrinol (Lausanne). 2021 May 3;12:669448. doi: 10.3389/fendo.2021.669448. PMID: 34012421; PMCID: PMC8126655. 
  • Garufi A, Giorno E, Gilardini Montani MS, Pistritto G, Crispini A, Cirone M, D'Orazi G. P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex. Biomolecules. 2021 Feb 25;11(3):348. doi: 10.3390/biom11030348. PMID: 33669070; PMCID: PMC7996602. 
  • Vahid F, Rahmani D. Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases? A systematic narrative review. Clin Nutr 2021 Jun;43:9-15. doi: 10.1016/j.clnesp.2021.04.009. Epub 2021 Apr 24. PMID: 34024569. 
  • Javed Z, Khan K, Rasheed A, Sadia H, Shahwani MN, Irshad A, Raza S, Salehi B, Sharifi-Rad J, Suleria HAR, Cruz-Martins N, Quispe C. Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention. Cancer Cell Int. 2021 Jan 26;21(1):77. doi: 10.1186/s12935-021-01777-3. PMID: 33499881; PMCID: PMC7836194. 

Vision 

  • Franzone F, Nebbioso M, Pergolizzi T, Attanasio G, Musacchio A, Greco A, Limoli PG, Artico M, Spandidos DA, Taurone S, Agostinelli E. Anti-inflammatory role of curcumin in retinal disorders (Review). Exp Ther Med. 2021 Jul;22(1):790. doi: 10.3892/etm.2021.10222. Epub 2021 May 21. PMID: 34055089; PMCID: PMC8145690. 
  • Kao YW, Hsu SK, Chen JY, Lin IL, Chen KJ, Lee PY, Ng HS, Chiu CC, Cheng KC. Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases. Int J Mol Sci. 2020 Dec 28;22(1):212. doi: 10.3390/ijms22010212. PMID: 33379248; PMCID: PMC7795090. 

Joints 

  • Thanawala S, Shah R, Somepalli V, Alluri KV, Desomayanandam P, Bhuvanendran A. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain. Clin Pharmacol. 2021 May 21;13:91-100. doi: 10.2147/CPAA.S307464. PMID: 34045905; PMCID: PMC8149286. 
  • Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705. PMID: 27533649; PMCID: PMC5003001. 

Anti-Inflammatory 

  • Ganji A, Farahani I, Saeedifar AM, Mosayebi G, Ghazavi A, Majeed M, Jamialahmadi T, Sahebkar A. Protective effects of curcumin against lipopolysaccharide-induced toxicity. Curr Med Chem. 2021 May 25. doi: 10.2174/0929867328666210525124707. Epub ahead of print. PMID: 34036908. 
  • Zhang ZB, Luo DD, Xie JH, Xian YF, Lai ZQ, Liu YH, Liu WH, Chen JN, Lai XP, Lin ZX, Su ZR. Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivoThrough Suppression of TAK1-NF-κB Pathway. Front Pharmacol. 2018 Oct 17;9:1181. doi: 10.3389/fphar.2018.01181. PMID: 30386242; PMCID: PMC6199526. 
  • Xie QF, Cheng JJ, Chen JF, Feng YC, Lin GS, Xu Y. Comparation of Anti-Inflammatory and Antioxidantactivities of Curcumin, Tetrahydrocurcuminand Octahydrocurcuminin LPS-Stimulated RAW264.7 Macrophages. Evid Based Complement Alternat Med. 2020 Dec 22;2020:8856135. doi: 10.1155/2020/8856135. PMID: 33424997; PMCID: PMC7772021. 

Anti-Aging 

  • Mahjoob M, Stochaj U. Curcumin nanoformulations to combat aging-related diseases. Ageing Res 2021 May 14;69:101364. doi: 10.1016/j.arr.2021.101364. Epub ahead of print. PMID: 34000462. 

Sleep 

  • Um MY, Yoon M, Lee J, Jung J, Cho S. A Novel Potent Sleep-Promoting Effect of Turmeric: Turmeric Increases Non-Rapid Eye Movement Sleep in Mice Via Histamine H1Receptor Blockade. Mol Nutr Food 2021 May 18:e2100100. doi: 10.1002/mnfr.202100100. Epub ahead of print. PMID: 34003596. 

Brain Health 

  • Yan FS, Sun JL, Xie WH, Shen L, Ji HF. Neuroprotective Effects and Mechanisms of Curcumin-Cu(II) and -Zn(II) Complexes Systems and Their Pharmacological Implications. Nutrients. 2017 Dec 28;10(1):28. doi: 10.3390/nu10010028. PMID: 29283372; PMCID: PMC5793256. 
  • Banerjee R. Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation. Bioinorg Chem Appl. 2014;2014:325873. doi: 10.1155/2014/325873. Epub 2014 Jul 23. PMID: 25147492; PMCID: PMC4134801. https://doi.org/10.1155/2014/325873 
  • Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neurol. 2008 Jan;11(1):13-9. 
  • Kulkarni SK, Dhir A. An overview of curcumin in neurological disorders. Indian J Pharm Sci. 2010 Mar;72(2):149-54. 
  • Pfeiffer CC, Braverman ER. Zinc, the brain and behavior. Biol Psychiatry. 1982 Apr;17(4):513- 32. 
  • Ahn WK, Proctor CC, Flanagan EH. Mental Health Clinicians' Beliefs About the Biological, Psychological, and Environmental Bases of Mental Disorders. Cogn Sci. 2009 Mar;33(2):147- 182.
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