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Created by a team of scientists and doctors, ProbioticSmart, LLC created 24hr Supplement to innovate science-backed nutrition that delivers optimal daily health support.

Our Story: We Put Turmeric to Work

Turmeric is a natural compound from the Curcuma longa plant that contains an amazing ingredient called Curcumin, which boasts a vast array of health benefits. Even so, Curcumin by itself is virtually useless due to its lack of bioavailability. But the scientists and doctors at 24hr Supplement discovered how to transform turmeric’s curcumin into a highly-absorbable ingredient that delivers a wide range of healthy benefits.

Background

The use of turmeric dates back nearly 4,000 years to the Vedic culture in India, where it was used as a culinary spice and had some religious significance. In 1280, Marco Polo described this spice, marveling at a vegetable that exhibited qualities so similar to that of saffron. Susruta’s Ayurvedic Compendium, dating back to 250 BC, recommends an ointment containing turmeric to relieve the effects of poisoned food.

Today, turmeric is widely cultivated in the tropics and goes by different names in different cultures and countries. Turmeric is a rhizomatous herbaceous perennial plant belonging to the ginger family Zingiberaceae, which is native to tropical South Asia. More than 100 components have been isolated from turmeric. Curcumin is one of the main biologically-active components that possesses antioxidant, anti‐inflammatory, anticancer, anti-arthritic, anti-atherosclerotic, anti-depressant, anti-aging, anti-diabetic, anti-microbial, wound healing and memory‐enhancing activities. As curcumin combats oxidative stress and reduces inflammatory mediators, it prevents the incidence of many inflammatory chronic disease. Over 65 clinical trials conducted on curcumin, have shown efficacy in various chronic conditions, including autoimmune, cardiovascular, diabetes, cancer, inflammatory bowel disease, pulmonary diseases, neurological, and psychological diseases. Because of its antiviral activities, curcumin has been shown effective against many viral diseases.

Curcumin has shown to be an immune stimulator. It induces both innate and adaptive arms of immunity through modulating immune cells’ function including neutrophils, macrophages, monocytes, natural killer cells (NK cells), dendritic cells (DCs), T cells, and B cells. Curcumin metabolizes to tetrahydrocurcumin, which has also high antioxidant and anti-inflammatory activities. Zinc (a vital trace mineral) has shown to proliferate the immune cells via regulating cell division and thus exerts immune boosting agent. Curcumin and zinc have a proven history of antiviral activity in both preclinical and clinical studies. Tetrahydrocurcumin is soluble in water and also has higher antioxidant activity than curcumin but lower anti-inflammatory activity.

Curcumin has shown to be an immune stimulator. It induces both innate and adaptive arms of immunity through modulating immune cells’ function including neutrophils, macrophages, monocytes, natural killer cells (NK cells), dendritic cells (DCs), T cells, and B cells. Curcumin metabolizes to tetrahydrocurcumin, which has also high antioxidant and anti-inflammatory activities. Zinc (a vital trace mineral) has shown to proliferate the immune cells via regulating cell division and thus exerts immune boosting agent. Curcumin and zinc have a proven history of antiviral activity in both preclinical and clinical studies. Tetrahydrocurcumin is soluble in water and also has higher antioxidant activity than curcumin but lower anti-inflammatory activity.

Circumventing Curcumin’s Poor Solubility

While curcumin possesses a wide variety of biological activities, a major obstacle to the clinical use of curcumin is related to its poor water solubility. However, scientists at 24hr Supplement found that bonding curcumin with certain metals, like Zinc, the solubility and stability questions are circumvented. Curcumin can undergo chelation with various metal ions, including zinc, to form metallo- curcumin complexes, which show greater effects as compared with curcumin alone. Metal-curcumin, or chelated curcumin, complexes increase the water solubility, cellular uptake, bioavailability as well as improve the antioxidant, anti-inflammatory, anti-microbial and antiviral effects of curcumin.

Therefore, a chelated curcumin, or metallocomplex of curcumin-zinc, solves the bioavailability question. The scientists at 24hr Supplement created a triple combination complex using Zinc, Curcumin and Tetrahydrocurcumin — which boasts extremely valuable antioxidant powers, to create a new complex called TurmiZn-OS™. For daily supplementation, there may not be another ingredient on this planet that contains so much potential wonders for wellness.

Meet TurmiZn-OS™ — The Triple-Action Complex

When 24hr Supplement decided to develop the most effective supplement to guard daily health, we asked our team of scientists to investigate Turmeric’s potential as a core ingredient. What they found is remarkable. Scientists discovered overwhelming evidence that metal-curcumin complexes, such as zinc-curcumin-tetrahydrocurcumin found in TurmiZn-OS™, not only solve curcumin’s bioavailability limitation but deliver a wide range of health-supporting properties, that they coined as “multi-anti” effects, in the most comprehensive review recently published in the noted peer-reviewed International Journal of Molecular Sciences.

The study, “Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin,” found the zinc-curcumin metal complex has antioxidant, anti-inflammatory, antiviral, antimicrobial, as well as having neuroprotective and immunomodulatory properties that aim at various disease states such as cancer, arthritis, osteoporosis, neurological disorders, diabetes, and ulcers to name a few.

That’s why every 24hr Supplement contains this core ingredient TurmiZn-OS™ which harnesses the power to support the antioxidant function, assist eliminating free radicals associated with the aging process, support the immune system, and help with conditions impacting joint, cardiovascular, brain health and much more.

24hr Supplement Transformed Turmeric to Guard Your Daily Health

Rajiv Lall

CEO of ProbioticSmart, LLC, M.S. Pharmacognosy, Department of Pharmacy, University of Minnesota, co-author of Nutraceuticals: Efficacy, Safety & Toxicity, published by Elsevier

Dr. Daniel DuBourdieu

Chief Scientist of Green Labs Maine, Ph.D. University of Minnesota, Dept. of Pharmacognosy and Medicinal Chemistry

Dr. Ramesh C. Gupta

Professor and Head of Toxicology Department at Breathitt Veterinary Center

Dr. W. T. Shier

Professor at Department of Medicinal Chemistry, University of Minnesota

Dr. Ajay Srivastava,

Adjunct Faculty at University of Wisconsin-Stout, Ph.D in Pharmacology, All India Institute of Medical Sciences (AIIMS), India

Dr. Sahdeo Prasad,

Scientist at Noble Pharma, Dept. of Immunotherapeutics and Biotechnology, Texas Tech University, Health Science Center, Abilene, Texas

24hr Supplement is led by Rajiv Lall, CEO, whose scientific research for the development of novel nutritional products and pharmaceuticals has helped produce 20 patents and several hundred formulations. Notably, Mr. Lall is also the Founder and CEO of Vets Plus, Inc., a leading manufacturer of science-based health food and supplements serving stock and companion animals. Recent awards include the Pet Age Icon Award (2015), and National Animal Supplement Council Visibility Award (2015). Mr. Lall and his wife, Swati, have developed the Raj and Swati Lall Microbiology Laboratory at the University of Wisconsin-Stout to support future scientists and business leaders in the community.

Noteworthy

• 24hr Supplement Immunity Approved As Dietary Supplement by Amazon®
• The Fight For Immunity Made Easy
• Creating A “New” Curcumin The Body Can Absorb
• Calming the “Cytokine Storm”